![]() ![]() Nine institutions are participating in Illumina's global early-access customer program to trial TSO 500 ctDNA v2. The assay provides additional flexibility with sequencing compatibility on the NovaSeq 6000 (NovaSeq 6000Dx in research mode and NovaSeq X coming in 2024), as well as local and cloud-based bioinformatics options accommodating the range of institutional preferences. Workflow improvements reduce hands-on time for library preparation, and automated bioinformatics features further streamline the experience. Flexible, streamlined, complete solution. The assay offers broader access to a sample-to-answer distributed solution in both manual and, coming in 2024, automated formats.At 10 ng input, it shows more than 95% sensitivity for hot-spot mutations with 99.9995% specificity. Improved performance can be attributed to both innovations in chemistry and the advanced variant analysis powered by DRAGEN. At 20 ng input, it shows more than 95% analytical sensitivity with 99.9995% specificity. More analytically sensitive assay with decreased input amounts. The assay enables analysis from as little as 5 to 30 nanograms (ng) of cfDNA input.Most ctDNA CGP assays have a turnaround time of one week or more, but in order for biomarker results to be the most valuable, users need insights sooner to better inform precision oncology efforts. Total turnaround time decreased to less than four days. Library preparation has been reduced to a single day, with improved chemistry requiring a single hybridization step, driving total turnaround time down to less than four days."Leading cancer centers are increasingly adopting the use of liquid-biopsy-based CGP, and with the TSO 500 ctDNA v2 assay we've aimed to make it easier for customers to integrate and enable deeper insights for cancer research," said Kevin Keegan, general manager of Oncology at Illumina. ![]() Key improvements include a faster sample-to-answer turnaround time of less than four days, higher sensitivity with lower cell-free DNA (cfDNA) input requirements, and a more streamlined workflow, which will be further enabled with automation in the first half of 2024. ![]()
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